posts: 49973

{
    "id": "wp-49973",
    "slug": "malaria-introduction",
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                        "text": "Our World in Data presents the data and research to make progress against the world\u2019s largest problems.",
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                        "text": "This article draws on data and research discussed in our entry on ",
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                                "url": "https://ourworldindata.org/malaria",
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                                    {
                                        "text": "Malaria",
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                        "text": ".",
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                        "text": "Malaria is a disease that is transmitted by infected mosquitoes. The bite of an infected Anopheles mosquito transmits a parasite that enters the victim\u2019s blood stream and travels into the person\u2019s liver where the parasite reproduces. The parasite, called plasmodium, causes a high fever that involves shaking chills and pain. In the worst cases malaria leads to coma and death.",
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                        "text": "The World Health Organization estimates that 241 million people contract the disease every year.{ref}Figures for 2020 according to the WHO: ",
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                    },
                    {
                        "url": "http://www.who.int/malaria/en/",
                        "children": [
                            {
                                "text": "http://www.who.int/malaria/en/",
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                        "text": " {/ref} Only a small fraction of malaria victims die from it, but those who die are the very weakest \u2013 about three out of four malaria victims are children.{ref}The WHO estimates that in 2020 (latest data, as of writing) 77% of all deaths were in children younger than 5 years old. The IHME\u2019s Global Burden of Disease also estimates that the majority of malaria deaths are in children younger than 5 years. According to their research the share of children younger than 5 among malaria victims fell slightly over the course of the last generation, from 66% in 1990 to 55% in 2019. Here is their data: ",
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                    },
                    {
                        "url": "https://ourworldindata.org/grapher/malaria-deaths-by-age?stackMode=relative%7B/ref",
                        "children": [
                            {
                                "text": "https://ourworldindata.org/grapher/malaria-deaths-by-age",
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                        "text": "{/ref} Malaria is one of the leading causes of child mortality; it kills about half a million children every year.{ref}These are the WHO estimates and are calculated based on the two previously cited statistics: 627,000*0.77=482,790.",
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                        "text": "To not suggest that we have a very precise knowledge of the number of children that die from malaria I have rounded the number from 482,790 to \u2018about half a million\u2019.",
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                        "text": "The ",
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                        "url": "https://ourworldindata.org/grapher/malaria-deaths-by-age",
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                            {
                                "text": "estimates of the Institute of Health Metrics and Evaluation (IHME)",
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                        "text": " \u2013\u00a0published in their Global Burden of Disease (GBD) study \u2013 are different: 643,000 malaria deaths in 2019; 356,000 of them are children younger than five. We have followed up with researchers in this field, but were not able to fully understand why the estimates from the IHME differ in their age-composition from the WHO estimates. To be on the conservative side I am relying on the estimates from the WHO throughout this text, but to provide perspective I also reference the IHME wherever relevant.",
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                        "text": "For more detail on this data see ",
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                    {
                        "url": "https://ourworldindata.org/malaria",
                        "children": [
                            {
                                "text": "our entry on malaria",
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                    {
                        "text": ".{/ref} That\u2019s 1320 dead children on any average day.",
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                "text": [
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                        "text": "How can the world make progress against malaria?",
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                        "text": "In the history of health, the most important progress is often made in the prevention \u2013 rather than the treatment \u2013 of disease. For infectious diseases, prevention means interrupting its transmission.",
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                "value": [
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                        "text": "Humanity\u2019s ",
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                        "url": "https://ourworldindata.org/microbes-battle-science-vaccines",
                        "children": [
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                                "text": "most ingenious",
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                        "text": " way of preventing infections is to achieve immunization through vaccines. The work on malaria vaccines goes back many decades, but unfortunately these vaccines have not been as successful as the vaccines against other diseases.{ref}Alphonse Laveran discovered already in 1880 that the Plasmodium parasite is the cause for malaria. But many attempts to develop vaccines were unsuccessful. Malaria vaccines such as SPf66 were insufficiently effective and until recently none of the scientific efforts led to a licensed vaccine. For an overview see Adrian V. S. Hill (2011) \u2013 Vaccines against malaria. In Philos Trans R Soc Lond B Biol Sci. 2011 Oct 12; 366(1579): 2806\u20132814. doi: 10.1098/rstb.2011.0091.\u00a0",
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                        "text": "This has changed somewhat with the malaria vaccine RTS,S, the world's first licensed malaria vaccine, which has been approved by European regulators in 2015. See RTS,S Clinical Trials Partnership (2015) \u2013 Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial. In The Lancet, Volume 386, ISSUE 9988, P31-45, July 04, 2015. Its efficacy is however not as high as that of other vaccines.{/ref}",
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                        "text": "There is however the hope that this will change. The mRNA technology \u2013 spurred by the ",
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                    },
                    {
                        "url": "https://owid.cloud/coronavirus",
                        "children": [
                            {
                                "text": "COVID pandemic",
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                            }
                        ],
                        "spanType": "span-link"
                    },
                    {
                        "text": " \u2013 ",
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                        "url": "https://www.vox.com/future-perfect/22307700/malaria-rna-vaccines-covid-19",
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                                "text": "seems promising",
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                        "text": " also for the prospect of a vaccine against malaria. But it will certainly still take some time until a highly efficacious malaria vaccine is widely available.",
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                        "text": "In the meantime the world has to protect itself from malaria in other ways. This is something the world has been getting increasingly successful at.\u00a0\u00a0",
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                "text": [
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                        "text": "Malaria was common across half the world \u2013 since then it has been eliminated in many regions",
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                        "text": "One line of humanity\u2019s attack is to progressively reduce the area where malaria is prevalent.\u00a0",
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                        "text": "Malaria is not a tropical disease. Rather, it is a disease that was eliminated everywhere but the tropics. Historically, malaria was prevalent in Europe and North America \u2013 Oliver Cromwell contracted the disease in Ireland, Friedrich Schiller in Mannheim, and Abraham Lincoln in Illinois.{ref}On the cause of Oliver Cromwell\u2019s death see ",
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                    },
                    {
                        "url": "http://www.olivercromwell.org/faqs8.htm",
                        "children": [
                            {
                                "text": "the FAQs at OliverCromwell.org",
                                "spanType": "span-simple-text"
                            }
                        ],
                        "spanType": "span-link"
                    },
                    {
                        "text": ", on Friedrich Schiller see ",
                        "spanType": "span-simple-text"
                    },
                    {
                        "url": "https://www.br.de/radio/bayern2/sendungen/radiowissen/deutsch-und-literatur/friedrich-schiller-thema100.html",
                        "children": [
                            {
                                "text": "Bayerischer Rundfunk here",
                                "spanType": "span-simple-text"
                            }
                        ],
                        "spanType": "span-link"
                    },
                    {
                        "text": ", on Abraham Lincoln see ",
                        "spanType": "span-simple-text"
                    },
                    {
                        "url": "http://www.physical-lincoln.com/books",
                        "children": [
                            {
                                "text": "\u2018The Physical Lincoln",
                                "spanType": "span-simple-text"
                            }
                        ],
                        "spanType": "span-link"
                    },
                    {
                        "text": "\u2019. Several popes also died of the disease as malaria was very prevalent in Italy until recently.\u00a0",
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                        "text": "It should however be noted that it is not always possible to diagnose the causes of death of historical figures. The claim that the German renaissance painter Albrecht D\u00fcrer died from malaria is for example disputed by Seitz, H. (2010) \u2013 \"Do der gelb fleck ist \u2026 \" D\u00fcrers Malaria, eine Fehldiagnose. Wien Klin Wochenschr 122, 10\u201313 (2010). ",
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                    },
                    {
                        "url": "https://doi.org/10.1007/s00508-010-1432-z",
                        "children": [
                            {
                                "text": "https://doi.org/10.1007/s00508-010-1432-z",
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                        "text": " {/ref}",
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                        "text": "The map shows that in modern times the disease has been eliminated not only there, but also in East Asia and Australia and in many parts of the Caribbean, South America, and Africa. Researchers estimate that historically \u2013 and up to around the year 1900 \u2013 our ancestors were at risk from malaria across about half of the world\u2019s land surface. Since then the area where humans are at risk of malaria contracted to a quarter.{ref}See the publication Simon I Hay, Carlos A Guerra, Andrew J Tatem, Abdisalan M Noor, and Robert W Snow (2004) \u2013 ",
                        "spanType": "span-simple-text"
                    },
                    {
                        "url": "https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(04)01043-6/fulltext",
                        "children": [
                            {
                                "text": "The global distribution and population at risk of malaria: past, present, and future",
                                "spanType": "span-simple-text"
                            }
                        ],
                        "spanType": "span-link"
                    },
                    {
                        "text": ". In The Lancet Infectious Diseases 2004 June; 4(6): 327\u2013336. DOI: 10.1016/S1473-3099(04)01043-6.\u00a0",
                        "spanType": "span-simple-text"
                    },
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                        "text": "The historical mapping of the prevalence of malaria is based on the pioneering work of Lysenko in the 1960s: Lysenko AJ, Semashko IN. Geography of malaria (1968) \u2013 A medico-geographic profile of an ancient disease. In: Lebedew AW, editor. Itogi Nauki: Medicinskaja Geografija. Academy of Sciences, USSR; Moscow: 1968. pp. 25\u2013146. Lysenko AJ, Beljaev AE (1969) \u2013 An analysis of the geographical distribution of Plasmodium ovale. Bull. World Health Organization; 40:383\u201394.",
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                        "text": "I have recreated that map and written about this research in Roser (2019) \u2013 ",
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                    },
                    {
                        "url": "https://ourworldindata.org/malaria-past-prevalence",
                        "children": [
                            {
                                "text": "Malaria was common across half the world \u2013 since then it has been eliminated in many regions",
                                "spanType": "span-simple-text"
                            }
                        ],
                        "spanType": "span-link"
                    },
                    {
                        "text": ". In Our World in Data.{/ref}\u00a0",
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                        "text": "This was achieved through the use of insecticides, the drainage of swampland, and better housing conditions. Economic growth was crucial for these developments so that the disease is today mostly prevalent in the world\u2019s poorest regions.",
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                        "text": "The often-repeated claim that malaria killed half of all humans who ever lived is very likely an overstatement, but it is certainly the case that the mosquito-borne fever was one of the most common causes of death in human history.{ref}That malaria was the most common cause of death was even suggested in a Nature article: Whitfield (2002) wrote \u201cMalaria may have killed half of all the people that ever lived\u201d.\u00a0",
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                        "text": "Whitfield, J. Portrait of a serial killer. Nature (2002). ",
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                    },
                    {
                        "url": "https://doi.org/10.1038/news021001-6",
                        "children": [
                            {
                                "text": "https://doi.org/10.1038/news021001-6",
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                        "text": "But while there is obviously no hard evidence to establish or refute this claim other epidemiologists were skeptical that this is true. Tim Harford investigated the claim in an episode of the BBC\u2019s \u201cMore or Less\u201d: ",
                        "spanType": "span-simple-text"
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                        "url": "https://www.bbc.co.uk/sounds/play/p01hnv98",
                        "children": [
                            {
                                "text": "Have Mosquitoes Killed Half the World?",
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                        "text": "{/ref} In the last few generations humanity gained ground in this long-lasting battle against the disease. The WHO reports that the global mortality rate has declined by 90% in the 20th century.{ref}See \u201cBox 4.1 Malaria-related mortality in the 20th century\u201d in the World Health Organization\u2019s",
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                        "url": "https://www.who.int/whr/1999/en/whr99_en.pdf",
                        "children": [
                            {
                                "text": " World Health Report (1999)",
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                        "text": ".{/ref}",
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                        "text": "\u2192 ",
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                        "children": [
                            {
                                "text": "More detail in my text ",
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                    {
                        "url": "https://ourworldindata.org/malaria-past-prevalence",
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                                "children": [
                                    {
                                        "text": "Malaria was common across half the world \u2013 since then it has been eliminated in many regions",
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            {
                "alt": "",
                "size": "wide",
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                "filename": "Previous-prevalence-of-malaria-world-map.png",
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                "text": [
                    {
                        "text": "Net Results: how the world is achieving progress where malaria is still prevalent",
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                "level": 2,
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                        "text": "Economic development is a slow process. Are there opportunities to protect people from malaria right now?",
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                        "text": "Yes. A surprisingly simple and cheap technology has saved the lives of millions of people in the last few years: insecticide-treated bed nets.",
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                        "text": "The nets protect those who sleep under them and the insecticide, with which they are impregnated, kills the mosquitoes \u2013 in this way the bed nets also protect their larger community, very similar to the way vaccinations do not only protect those who receive the vaccine, but also those around them. Such public health measures which protect the individual and the people they are in contact with are particularly successful ways to fight global problems.",
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                        "text": "The progress against malaria since the turn of the century is shown in the two visualizations below. The map shows us the change in child mortality due to malaria on the local-level across Africa (for which 2019 is the latest data). The global annual death toll \u2013 across all ages \u2013 declined from 900,000 to 630,000 per year. It also shows that the disruptions due to the pandemic led to an increase in malaria deaths.",
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                        "text": "How was this progress possible? The study by Samir Bhatt and colleagues{ref}Bhatt et al. (2015) \u2013 ",
                        "spanType": "span-simple-text"
                    },
                    {
                        "url": "https://www.nature.com/articles/nature15535",
                        "children": [
                            {
                                "text": "The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015",
                                "spanType": "span-simple-text"
                            }
                        ],
                        "spanType": "span-link"
                    },
                    {
                        "text": ". Nature 526, 207\u2013211 (08 October 2015) doi:10.1038/nature15535",
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                    },
                    {
                        "spanType": "span-newline"
                    },
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                        "text": "The focus of the study was Africa, where \u2013 as the chart shows \u2013 most of the recent reduction was achieved.{/ref} in Nature found that three health measures were particularly important for progress against malaria in Africa. By far the most important measure was the just-mentioned distribution of insecticide-treated bed nets; about ",
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                    },
                    {
                        "children": [
                            {
                                "text": "two-thirds",
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                            }
                        ],
                        "spanType": "span-italic"
                    },
                    {
                        "text": " of the averted cases can be attributed to bed nets. The rest was achieved thanks to indoor residual spraying and the treatment of malaria cases with artemisinin, a drug discovered by Tu Youyou. She was awarded the Nobel Prize in Medicine in 2015 for this achievement.",
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                "left": [
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                            {
                                "children": [
                                    {
                                        "text": "Malaria mortality rate of children in 2000 and 2019",
                                        "spanType": "span-simple-text"
                                    }
                                ],
                                "spanType": "span-bold"
                            },
                            {
                                "text": "{ref}Citation: Institute for Health Metrics and Evaluation (IHME), Malaria Atlas Project. Global Malaria Incidence, Prevalence, and Mortality Geospatial Estimates 2000-2019. Seattle, United States of America: Institute for Health Metrics and Evaluation (IHME), 2020. ",
                                "spanType": "span-simple-text"
                            },
                            {
                                "url": "https://doi.org/10.6069/CG0J-2R97",
                                "children": [
                                    {
                                        "text": "https://doi.org/10.6069/CG0J-2R97",
                                        "spanType": "span-simple-text"
                                    }
                                ],
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                            {
                                "text": "Shown is the mortality rate due to plasmodium falciparum \u2013 direct link to the interactive maps as published by the IHME ",
                                "spanType": "span-simple-text"
                            },
                            {
                                "url": "http://ihmeuw.org/5dhp",
                                "children": [
                                    {
                                        "text": "http://ihmeuw.org/5dhp",
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                            {
                                "text": "For the background see: Weiss, D. J., Lucas, T. C. D., Nguyen, M., Nandi, A. K., Bisanzio, D., Battle, K. E., Cameron, E., Twohig, K. A., Pfeffer, D. A., Rozier, J. A., Gibson, H. S., Rao, P. C., Casey, D., Bertozzi-Villa, A., Collins, E. L., Dalrymple, U., Gray, N., Harris, J. R., Howes, R. E., \u2026 Gething, P. W. (2019) \u2013 ",
                                "spanType": "span-simple-text"
                            },
                            {
                                "url": "https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)31097-9/fulltext",
                                "children": [
                                    {
                                        "text": "Mapping the global prevalence, incidence, and mortality of Plasmodium falciparum, 2000\u201317: A spatial and temporal modelling study",
                                        "spanType": "span-simple-text"
                                    }
                                ],
                                "spanType": "span-link"
                            },
                            {
                                "text": ". In The Lancet, 394(10195), 322\u2013331. ",
                                "spanType": "span-simple-text"
                            },
                            {
                                "url": "https://doi.org/10.1016/S0140-6736(19)31097-9",
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                        "text": "We can achieve more and you can help",
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                        "text": "Progress never happens by itself. For millennia our ancestors were exposed to the malaria parasite without defense; the fact that this changed is the achievement of the scientific, political, and economic achievements of the last few generations.",
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                        "text": "Today we are in the fortunate situation that we have several decades of progress behind us: We can look back and study what worked to use this knowledge to go further.\u00a0",
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                        "text": "Some of the most important research in global development asks the question of where additional efforts can do the most good. A charity evaluator that is doing very rigorous work on this is \u2018GiveWell\u2019. Their research tells you where your donation can have the largest positive impact. It finds that donations to support the fight against malaria are one of the very most impactful ways for you to donate. At the top of GiveWell\u2019s recommended charities are two organizations that work towards that goal: the ",
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                                "text": "Against Malaria Foundation ",
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                        "text": "and the ",
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                        "text": ".\u00a0",
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                        "text": "Continuing the successful fight against malaria requires commitment from governments around the world. It is a problem that we might be able to solve with better technology in the future \u2013 most likely with a vaccine \u2013 if we choose to support scientific research.\u00a0",
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                        "text": "But it is also a problem where each of us can individually contribute to progress right now. You can read the research about how your donation can contribute to progress against malaria here: ",
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                        "url": "https://www.givewell.org/",
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                        "text": ". If you want to contribute to this progress it is possible to make a donation right there.",
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                        "text": "We do not have to live in a world in which 1320 children die from a preventable disease every day.",
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        "title": "Malaria: One of the leading causes of child deaths, but progress is possible and you can contribute to it",
        "authors": [
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        "excerpt": "We do not have to live in a world in which 1320 children die from a preventable disease every day.",
        "dateline": "March 22, 2022",
        "subtitle": "We do not have to live in a world in which 1320 children die from a preventable disease every day.",
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